Janbernd Kirschner Selected Research

Zalcitabine (Hivid)

12/2010	Role of pyrimidine depletion in the mitochondrial cardiotoxicity of nucleoside analogue reverse transcriptase inhibitors.
1/2010	Oral uridine supplementation antagonizes the peripheral neuropathy and encephalopathy induced by antiretroviral nucleoside analogues.
1/2008	Uridine supplementation antagonizes zidovudine-induced mitochondrial myopathy and hyperlactatemia in mice.
1/2007	Uridine supplementation antagonizes zalcitabine-induced microvesicular steatohepatitis in mice.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Janbernd Kirschner Research Topics

Disease

17	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 07/2022 - 01/2017
10	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022 - 11/2010
10	Muscular Diseases (Myopathy) 10/2021 - 01/2005
4	Muscle Weakness 10/2021 - 01/2005
4	Muscular Dystrophies (Muscular Dystrophy) 08/2014 - 09/2008
3	Disease Progression 07/2021 - 01/2019
3	Cardiomyopathies (Cardiomyopathy) 10/2019 - 09/2010
3	Mitochondrial Myopathies (Mitochondrial Myopathy) 01/2018 - 01/2008
3	Scleroatonic muscular dystrophy 01/2013 - 01/2005
2	Fever (Fevers) 01/2022 - 01/2017
2	Vomiting 01/2022 - 01/2017
2	Rhabdomyolysis 10/2021 - 01/2020
2	Epilepsy (Aura) 07/2021 - 02/2015
2	Brain Diseases (Brain Disorder) 01/2020 - 01/2010
2	Neuromuscular Diseases (Neuromuscular Disease) 01/2020 - 03/2014
2	Lactic Acidosis 01/2020 - 02/2012
2	Scoliosis 04/2019 - 05/2012
2	Cough 01/2019 - 01/2017
2	Mitochondrial Diseases (Mitochondrial Disease) 06/2015 - 01/2010
2	Hypertrophy 01/2014 - 12/2007
2	Proteostasis Deficiencies 03/2013 - 01/2013
2	Myofibrillar Myopathy 01/2013 - 12/2007
2	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2011 - 02/2004
2	Cardiotoxicity 12/2010 - 09/2010
1	Exanthema (Rash) 01/2022
1	Pneumonia (Pneumonitis) 01/2022
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2022
1	Arthralgia (Joint Pain) 01/2022
1	Aphthous Stomatitis (Aphthous Ulcer) 01/2022
1	Urinary Tract Infections (Urinary Tract Infection) 01/2022
1	Diarrhea 01/2022
1	Failure to Thrive 01/2022
1	Myalgia 10/2021
1	Coma (Comas) 07/2021
1	Infections 07/2021
1	Severe combined immunodeficiency due to adenosine deaminase deficiency 12/2020
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 12/2020
1	Retinal Dystrophies 12/2020
1	Thalassemia 12/2020
1	Cognitive Dysfunction 01/2020
1	2-Hydroxyglutaricaciduria 01/2020
1	Hypoglycemia (Reactive Hypoglycemia) 01/2020
1	Critical Illness (Critically Ill) 12/2019
1	Potassium aggravated myotonia 11/2019
1	Left Ventricular Dysfunction 10/2019
1	Post-Dural Puncture Headache 01/2019
1	Polyneuropathies (Polyneuropathy) 09/2018
1	Molybdenum cofactor deficiency 01/2018
1	Low Cardiac Output 01/2017
1	Nasopharyngitis 01/2017
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2017
1	Nemaline Myopathies (Nemaline Myopathy) 05/2015
1	Traumatic Brain Injuries (Traumatic Brain Injury) 02/2015

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 07/2022 - 02/2004
10	nusinersenIBA 01/2022 - 11/2017
7	Mitochondrial DNA (mtDNA)IBA 01/2014 - 01/2007
5	Zidovudine (Retrovir)FDA LinkGeneric 01/2014 - 01/2008
4	Nonsense Codon (Nonsense Mutation)IBA 10/2020 - 02/2012
4	NucleosidesIBA 10/2012 - 01/2008
4	Zalcitabine (Hivid)FDA Link 12/2010 - 01/2007
4	UridineIBA 12/2010 - 01/2007
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 05/2012
3	atalurenIBA 10/2020 - 01/2017
3	SteroidsIBA 09/2018 - 11/2010
3	EnzymesIBA 01/2018 - 12/2007
3	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2018 - 01/2010
3	FilaminsIBA 01/2013 - 12/2007
3	Reverse Transcriptase InhibitorsIBA 10/2012 - 01/2008
2	RisdiplamIBA 07/2022 - 01/2022
2	Prednisone (Sone)FDA LinkGeneric 01/2022 - 11/2010
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2019
2	Creatine Kinase (Creatine Phosphokinase)IBA 10/2021 - 08/2014
2	Pharmaceutical PreparationsIBA 07/2021 - 05/2012
2	olesoximeIBA 12/2020 - 01/2017
2	salicylhydroxamic acid (SHAM)IBA 01/2018 - 11/2017
2	Laminin (Merosin)IBA 08/2014 - 01/2013
2	pyrimidineIBA 12/2010 - 01/2008
2	Lamin Type A (Lamin A)IBA 01/2005 - 02/2004
1	Cathepsin DIBA 01/2022
1	deflazacortIBA 01/2022
1	GlycogenIBA 01/2022
1	Adrenocorticotropic Hormone (ACTH)FDA Link 07/2021
1	Anesthetics (Anesthetic Agents)IBA 07/2021
1	Antisense OligonucleotidesIBA 01/2021
1	ZolgensmaIBA 01/2021
1	citrate-binding transport proteinIBA 01/2020
1	Sodium Channels (Sodium Channel)IBA 11/2019
1	Metoprolol (Toprol-XL)FDA LinkGeneric 10/2019
1	Enalapril FDA LinkGeneric 10/2019
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/2019
1	prednylidene (Pred)IBA 01/2019
1	Immunosuppressive Agents (Immunosuppressants)IBA 09/2018
1	nebulinIBA 05/2015

Therapy/Procedure

7	Therapeutics 12/2020 - 04/2006
1	Palliative Care (Palliative Therapy) 12/2020
1	Mechanical Ventilators (Ventilator) 12/2019
1	Punctures 01/2019
1	Heart-Assist Devices 01/2017
1	Extracorporeal Membrane Oxygenation 01/2017
1	Cardiopulmonary Resuscitation (CPR) 01/2017